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Methylfolate (Quatrefolic)
Supplements
Nutri-ScoreB

Methylfolate (Quatrefolic)

Pteroylmonoglutamic acid

Clinical Encyclopedia

SM
Nutri-Score & Health Summary

Methylfolate (Quatrefolic) provides 0 kcal, 0g of protein, 0g of carbohydrates, and 0g of fiber per 100g. With a Nutri-Score grade 'B', it is a highly recommended option for nutrient density.

Methylfolate is the active form of folate, essential for DNA synthesis and repair, and plays a crucial role in cellular division and growth. Quatrefolic is a patented form of methylfolate that is more bioavailable and stable than traditional folic acid.

Also known as:
L-methylfolate5-MTHF
Scientific NamePteroylmonoglutamic acid
Region of OriginUnited States

Macronutrient Ratio

Caloric distribution of primary energy metrics per 100g

Calories0 kcal
Water
0%
Fiber0g
Total0.0g
Protein
0g(0%)
Fats
0g(0%)
Carbohydrates
0g(0%)

Micronutrient DV% Score

Top vitamins and minerals ranked by percentage of Daily Recommended Value

Vitamins (DV%)
Minerals (DV%)

Complete Micronutrient Breakdown

Detailed concentration of essential micronutrients per 100g serving.

Vitamins

Major Source (≥ 2% DV)
Folate400 mcg (100%)
Vitamins with less than 2% DVNone registered

Minerals

Major Source (≥ 2% DV)None registered
Minerals with less than 2% DVNone registered

Health Benefits

Supports proper brain function and mental health by aiding neurotransmitter synthesis.
Essential for pregnant women as it reduces the risk of neural tube defects in the developing fetus.
Helps in the metabolism of homocysteine, potentially lowering the risk of cardiovascular diseases.
May improve mood and reduce symptoms of depression by enhancing folate levels in the brain.

Possible Risks & Side Effects

!Excessive intake may mask vitamin B12 deficiency symptoms, leading to neurological damage.
!Individuals with certain genetic mutations (e.g., MTHFR) may experience adverse effects if not monitored.

How to Prepare & Consume

Methylfolate supplements can be taken orally, preferably with food to enhance absorption. Consult a healthcare provider for appropriate dosage.

Smart Selection & Storage

How to Select

Choose methylfolate supplements that are labeled as 'bioactive' or 'Quatrefolic' for better absorption. Check for third-party testing for quality assurance.

How to Store

Store in a cool, dry place away from direct sunlight to maintain potency.

Myths vs Realities

MythMethylfolate is the same as folic acid.
RealityMethylfolate is the bioactive form of folate, while folic acid must be converted in the body, which some individuals cannot do efficiently.
MythTaking more methylfolate is always better.
RealityExcessive methylfolate can mask vitamin B12 deficiency, leading to serious health issues.
MythMethylfolate can cure depression.
RealityWhile it may help improve mood, methylfolate is not a standalone treatment for depression and should be part of a comprehensive treatment plan.

Healthy Recipes

Methylfolate-Infused Quinoa Salad

A vibrant salad packed with nutrients, featuring quinoa, fresh vegetables, and a methylfolate boost for optimal health.

Ingredients
  • 1 cup cooked quinoa
  • 1/2 cup cherry tomatoes, halved
  • 1/2 cucumber, diced
  • 1/4 cup red onion, finely chopped
  • 1/4 cup feta cheese, crumbled
  • 2 tablespoons olive oil
  • 1 tablespoon lemon juice
  • Salt and pepper to taste
  • 1 serving methylfolate supplement
Instructions
  1. 1. In a large bowl, combine the cooked quinoa, cherry tomatoes, cucumber, red onion, and feta cheese.
  2. 2. In a small bowl, whisk together olive oil, lemon juice, salt, and pepper.
  3. 3. Pour the dressing over the salad, mix well, and add the methylfolate supplement before serving.

Methylfolate Smoothie Bowl

A delicious smoothie bowl that combines fruits, greens, and a methylfolate kick, perfect for a nutritious breakfast.

Ingredients
  • 1 banana
  • 1/2 cup spinach
  • 1/2 cup almond milk
  • 1 tablespoon almond butter
  • 1 serving methylfolate supplement
  • Toppings: sliced fruits, chia seeds, granola
Instructions
  1. 1. Blend banana, spinach, almond milk, almond butter, and methylfolate until smooth.
  2. 2. Pour the smoothie into a bowl.
  3. 3. Top with sliced fruits, chia seeds, and granola before serving.

Methylfolate-Packed Veggie Omelette

A fluffy omelette loaded with colorful vegetables and a methylfolate boost, perfect for a healthy breakfast or brunch.

Ingredients
  • 3 eggs
  • 1/4 cup bell peppers, diced
  • 1/4 cup spinach
  • 1/4 cup mushrooms, sliced
  • Salt and pepper to taste
  • 1 serving methylfolate supplement
Instructions
  1. 1. Whisk the eggs in a bowl and season with salt and pepper.
  2. 2. In a non-stick skillet, sauté bell peppers, spinach, and mushrooms until tender.
  3. 3. Pour the eggs over the veggies, cook until set, and add the methylfolate supplement before folding the omelette.

Methylfolate-Enhanced Lentil Soup

A hearty lentil soup enriched with vegetables and a methylfolate boost, perfect for a comforting meal.

Ingredients
  • 1 cup lentils, rinsed
  • 1 carrot, diced
  • 1 celery stalk, diced
  • 1 onion, chopped
  • 4 cups vegetable broth
  • 1 tablespoon olive oil
  • 1 serving methylfolate supplement
  • Salt and pepper to taste
Instructions
  1. 1. In a pot, heat olive oil and sauté onion, carrot, and celery until soft.
  2. 2. Add lentils and vegetable broth, bring to a boil, then simmer until lentils are tender.
  3. 3. Stir in the methylfolate supplement before serving.

Methylfolate-Infused Chickpea Salad

A protein-packed chickpea salad with fresh herbs and a methylfolate boost, ideal for a light lunch or snack.

Ingredients
  • 1 can chickpeas, drained and rinsed
  • 1/2 cup parsley, chopped
  • 1/4 cup red onion, diced
  • 1/4 cup olive oil
  • 2 tablespoons lemon juice
  • Salt and pepper to taste
  • 1 serving methylfolate supplement
Instructions
  1. 1. In a bowl, combine chickpeas, parsley, and red onion.
  2. 2. Whisk together olive oil, lemon juice, salt, and pepper, then pour over the salad.
  3. 3. Mix well and add the methylfolate supplement before serving.

Methylfolate-Boosted Sweet Potato Mash

A creamy and nutritious sweet potato mash enriched with methylfolate, perfect as a side dish.

Ingredients
  • 2 large sweet potatoes, peeled and cubed
  • 2 tablespoons butter or olive oil
  • Salt and pepper to taste
  • 1 serving methylfolate supplement
Instructions
  1. 1. Boil sweet potatoes until tender, then drain.
  2. 2. Mash the sweet potatoes with butter or olive oil, seasoning with salt and pepper.
  3. 3. Stir in the methylfolate supplement before serving.

Methylfolate-Infused Berry Chia Pudding

A delightful chia pudding layered with berries and a methylfolate boost, perfect for breakfast or dessert.

Ingredients
  • 1/4 cup chia seeds
  • 1 cup almond milk
  • 1 tablespoon honey or maple syrup
  • 1/2 cup mixed berries
  • 1 serving methylfolate supplement
Instructions
  1. 1. In a bowl, mix chia seeds, almond milk, and honey or maple syrup.
  2. 2. Refrigerate for at least 4 hours or overnight until thickened.
  3. 3. Top with mixed berries and stir in the methylfolate supplement before serving.

Methylfolate-Enhanced Zucchini Noodles

A light and healthy dish featuring zucchini noodles tossed with a flavorful sauce and a methylfolate boost.

Ingredients
  • 2 medium zucchinis, spiralized
  • 1 cup cherry tomatoes, halved
  • 2 tablespoons olive oil
  • 2 cloves garlic, minced
  • Salt and pepper to taste
  • 1 serving methylfolate supplement
Instructions
  1. 1. In a skillet, heat olive oil and sauté garlic until fragrant.
  2. 2. Add cherry tomatoes and cook until softened, then toss in zucchini noodles.
  3. 3. Season with salt and pepper, and stir in the methylfolate supplement before serving.

Methylfolate-Infused Oatmeal Bowl

A wholesome oatmeal bowl topped with fruits and nuts, enhanced with a methylfolate boost for a nutritious start to your day.

Ingredients
  • 1 cup rolled oats
  • 2 cups almond milk
  • 1 banana, sliced
  • 1/4 cup walnuts, chopped
  • 1 tablespoon honey
  • 1 serving methylfolate supplement
Instructions
  1. 1. Cook oats in almond milk according to package instructions.
  2. 2. Once cooked, stir in honey and top with banana slices and walnuts.
  3. 3. Add the methylfolate supplement before serving.

Methylfolate-Boosted Grilled Chicken Salad

A protein-rich grilled chicken salad with fresh greens and a methylfolate boost, perfect for a satisfying meal.

Ingredients
  • 1 chicken breast, grilled and sliced
  • 2 cups mixed greens
  • 1/4 cup cherry tomatoes, halved
  • 1/4 cucumber, sliced
  • 2 tablespoons balsamic vinaigrette
  • 1 serving methylfolate supplement
Instructions
  1. 1. In a bowl, combine mixed greens, cherry tomatoes, and cucumber.
  2. 2. Top with sliced grilled chicken and drizzle with balsamic vinaigrette.
  3. 3. Add the methylfolate supplement before serving.

Frequently Asked Questions (FAQ)

What is the difference between methylfolate and folic acid?

Methylfolate is the active form of folate that the body can use directly, while folic acid is a synthetic form that needs to be converted into methylfolate.

Can I take methylfolate if I am pregnant?

Yes, methylfolate is recommended during pregnancy to help prevent neural tube defects.

How much methylfolate should I take daily?

The recommended daily allowance for adults is typically 400 mcg, but consult a healthcare provider for personalized advice.

Are there any side effects of taking methylfolate?

Some individuals may experience gastrointestinal upset or insomnia; consult a healthcare provider if symptoms persist.

Can methylfolate help with depression?

Yes, studies suggest that adequate levels of folate can improve mood and reduce depressive symptoms.

Is methylfolate safe for everyone?

While generally safe, individuals with specific genetic mutations should consult a healthcare provider before use.

How does methylfolate affect homocysteine levels?

Methylfolate helps convert homocysteine into methionine, potentially lowering elevated homocysteine levels associated with cardiovascular risk.

Can I get enough methylfolate from my diet?

Foods rich in folate include leafy greens, legumes, and fortified cereals, but supplementation may be necessary for some individuals.